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Amphiregulin binds to EGF Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84 amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252 amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGF alpha, AR, HB EGF, cripto 1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Our Abpromise guarantee covers the use of ab2993 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at 10 µg/mg of lysate.
With protein A, native.
ab2993 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"