Overview

  • Product nameAnti-AMSH antibody
    See all AMSH primary antibodies
  • Description
    Rabbit polyclonal to AMSH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 362-391 of Human AMSH (NP_964010.1, NP_998787.1, NP_006454.1).

  • Positive control
    • A549 cell line lysates, mouse cerebellum tissue lysates

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 48 kDa.

Target

  • FunctionZinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the peptidase M67C family.
    Contains 1 MPN (JAB/Mov34) domain.
  • DomainThe JAMM motif is essential for the protease activity.
  • Post-translational
    modifications
    Phosphorylated after BMP type I receptor activation.
    Ubiquitinated by SMURF2 in the presence of RNF11.
  • Cellular localizationNucleus. Membrane. Cytoplasm. Early endosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • AMSH antibody
    • Associated molecule with the SH3 domain of STAM antibody
    • Endosome associated ubiquitin isopeptidase antibody
    • Endosome-associated ubiquitin isopeptidase antibody
    • MGC126516 antibody
    • MGC126518 antibody
    • MICCAP antibody
    • STABP_HUMAN antibody
    • STAM binding protein antibody
    • STAM-binding protein antibody
    • Stambp antibody
    see all

Anti-AMSH antibody images

  • Anti-AMSH antibody (ab113053) at 1/100 dilution + A549 cell line lysates at 35 µg

    Predicted band size : 48 kDa
  • Anti-AMSH antibody (ab113053) at 1/100 dilution + Mouse cerebellum tissue lysates at 35 µg

    Predicted band size : 48 kDa

References for Anti-AMSH antibody (ab113053)

ab113053 has not yet been referenced specifically in any publications.

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