FunctionZinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Tissue specificityUbiquitously expressed.
Sequence similaritiesBelongs to the peptidase M67C family. Contains 1 MPN (JAB/Mov34) domain.
DomainThe JAMM motif is essential for the protease activity.
Post-translational modificationsPhosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11.
Cellular localizationNucleus. Membrane. Cytoplasm. Early endosome.