FunctionSelectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Sequence similaritiesBelongs to the calcitonin family.
DomainThe mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.
Post-translational modificationsAmyloid fibrils are degraded by IDE.