Overview

  • Product nameAmyloid β Peptide (1-42) (human)
  • Description
    Amyloid-β (1-42) protein fragment. Implicated in Alzheimer's disease.
  • Alternative names
    • AB42
  • Biological description

    42-Residue amyloid β-protein fragment; the predominant form of amyloid β found in the brains of people with Alzheimer's disease and Down's syndrome. Neurotoxic. Shown to induce neuronal death via actions at the p75 neurotrophin receptor.

Properties

    Protocols

    References for Amyloid β Peptide (1-42) (human) (ab120301)

    This product has been referenced in:
    • Sotthibundhu A  et al. Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci 28:3941-6 (2008). Read more (PubMed: 18400893) »
    • Nagele RG  et al. Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110:199-211 (2002). Read more (PubMed: 11958863) »
    • Roher AE  et al. beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A 90:10836-40 (1993). Read more (PubMed: 8248178) »

    See all 2 Publications for this product

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