Overview

  • Product name
    Amyloid β Peptide (1-43) (Aβ43)
  • Description
    Highly toxic, amyloidogenic amyloid β (1-43) peptide fragment
  • Biological description

    Amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42 (ab120479 / ab120301). Aggregates and is potently amyloidogenic in vivo. Induces synaptic dysfunction and impairs memory.

  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Saito T  et al. Potent amyloidogenicity and pathogenicity of Aß43. Nat Neurosci 14:1023-32 (2011). Read more (PubMed: 21725313) »
  • Jarrett JT  et al. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-7 (1993). Read more (PubMed: 8490014) »
  • Hilbich C  et al. Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4. Eur J Biochem 201:61-9 (1991). Read more (PubMed: 1915378) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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