Anti-Amyloid Precursor Protein Frameshift Mutant antibody (ab2085)

Overview

  • Product name
    Anti-Amyloid Precursor Protein Frameshift Mutant antibody
    See all Amyloid Precursor Protein Frameshift Mutant primary antibodies
  • Description
    Goat polyclonal to Amyloid Precursor Protein Frameshift Mutant
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Amyloid Precursor Protein Frameshift Mutant aa 339-348 (C terminal). Frameshift sequence from Figure 1, van Leeuwen, et.al., Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer’s and Down Patients, Science, Vol. 279, 9 Jan 1998, 242-247.

Properties

Applications

Our Abpromise guarantee covers the use of ab2085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
WB 1/3000. Detects a band of approximately 45 kDa.
IHC-P 1/300.

Target

  • Relevance
    Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimers disease patients and Downs Syndrome patients.
  • Cellular localization
    Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus
  • Database links
  • Alternative names
    • AAA antibody
    • ABETA antibody
    • ABPP antibody
    • AD1 antibody
    • APP antibody
    • APPI antibody
    see all

References

ab2085 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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