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Synthetic peptide within Human Amyloid Precursor Protein aa 750 to the C-terminus (C terminal) (phospho Y757) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
(Peptide available as
Phosphorylation of APP at Tyr757 and 762 is important for MAPK8IP1, APBA1, shcA/shcC and DAB1 binding. Binding interactions regulated by phosphorylation determine the localisation and the function of APP. Therefore Amyloid Precursor Protein (phospho Y757) antibody will be a useful tool in tracing the processing, distribution and interaction of APP.
Our Abpromise guarantee covers the use of ab19850 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55, 87, 110, 170 kDa (predicted molecular weight: 55, 87, 110 kDa).|
This image is courtesy of Florian Plattner, Wolfson Inst Biomed Research, United Kingdom
Rabbit polyclonal to APP (phospho Y757) ab19850 recognises various isoforms of APP in the phosphorylated state including the mature (around 80 kDa) and immature (around 110 kDa) APP isoforms. ab19850 also detects several C-terminal fragments around 50 kDa which are well documented in public databases (e.g Swiss Prot, EMBL). The band around 170 kDa could not be assigned to APP, but is possibly an isoform of APP.
ab19850 has not yet been referenced specifically in any publications.