Overview

  • Product nameAnti-Angiogenin antibody
    See all Angiogenin primary antibodies
  • Description
    Rabbit polyclonal to Angiogenin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 70-101 of Human Angiogenin (NP_001136).

  • Positive control
    • Jurkat cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab107065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 17 kDa.

Target

  • FunctionMay function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
  • Tissue specificityExpressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
  • Involvement in diseaseDefects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
  • Sequence similaritiesBelongs to the pancreatic ribonuclease family.
  • Developmental stageLow level expression in the developing fetus, increased in the neonate, and maximal in the adult.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALS9 antibody
    • AMYOTROPHIC LATERAL SCLEROSIS antibody
    • ANG 1 antibody
    • ANG antibody
    • ANG I antibody
    • ANG1 antibody
    • ANGI antibody
    • ANGI_HUMAN antibody
    • Angiogenin antibody
    • Angiogenin ribonuclease RNase A family, 5 antibody
    • Epididymis luminal protein 168 antibody
    • HEL168 antibody
    • MGC22466 antibody
    • MGC71966 antibody
    • Ribonuclease 5 antibody
    • Ribonuclease RNase A Family 5 antibody
    • RNase 5 antibody
    • RNASE4 antibody
    • RNASE5 antibody
    see all

Anti-Angiogenin antibody images

  • Anti-Angiogenin antibody (ab107065) at 1/100 dilution + Jurkat cell lysate at 35 µg

    Predicted band size : 17 kDa

References for Anti-Angiogenin antibody (ab107065)

ab107065 has not yet been referenced specifically in any publications.

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