FunctionMay function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Tissue specificityExpressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Involvement in diseaseDefects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
Sequence similaritiesBelongs to the pancreatic ribonuclease family.
Developmental stageLow level expression in the developing fetus, increased in the neonate, and maximal in the adult.