SpecificityThis antibody shows no cross-reactivity with recombinant human
angiopoietin-2, recombinant human angiopoietin-4, recombinant mouse angiopoietin-like 3, and recombinant human cornea-derived transcript 6 (CDT-6).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 1 µg/ml.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 58 kDa.
FunctionBinds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.