Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab109637 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking - Blocking peptide for Anti-Angiopoietin 1 antibody (ab95230)

    • Purity
      70 - 90% by HPLC.

    • Additional notes

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

      Information available upon request.

    General Info

    • Alternative names
      • AGP 1
      • AGP1
      • AGPT
      • ANG
      • ANG 1
      • ANG-1
      • ANG1
      • Angiopoietin-1
      • Angiopoietin1
      • ANGP1_HUMAN
      • ANGPT 1
      • Angpt1
      • KIAA0003
      • OTTHUMP00000227592
      • OTTHUMP00000227599
      • OTTHUMP00000227600
      see all
    • Function
      Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
    • Sequence similarities
      Contains 1 fibrinogen C-terminal domain.
    • Post-translational
      modifications
      Glycosylated.
    • Cellular localization
      Secreted.
    • Information by UniProt

    References

    This product has been referenced in:
    • Gu H  et al. Angiopoietin-1 and Angiopoietin-2 Expression Imbalance Influence in Early Period After Subarachnoid Hemorrhage. Int Neurourol J 20:288-295 (2016). Read more (PubMed: 28043115) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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