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Rabbit polyclonal to Angiopoietin 2
At least three isoforms of ANGPT2 are known to exist; this antibody will detect all three isoforms.
Mouse, Rat, Human
Synthetic peptide corresponding to 18 amino acids near the carboxy terminus of Human Angiopoietin 2 protein (O15123).
Human Liver Tissue Lysate.
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
Immunogen affinity purified
Immunizing Peptide (Blocking)
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2.5 µg/ml.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 56 kDa.Can be blocked with
Human Angiopoietin 2 peptide (ab172727).
Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Contains 1 fibrinogen C-terminal domain.
The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
Information by UniProt
AGPT 2 antibody
ANG 2 antibody
Western blot - Anti-Angiopoietin 2 antibody (ab125692)
Lane 1 : Anti-Angiopoietin 2 antibody (ab125692) at 1 µg/ml Lane 2 : Anti-Angiopoietin 2 antibody (ab125692) at 2 µg/ml Lane 1 : Human liver tissue lysate Lane 2 : Human liver tissue lysate Lysates/proteins at 15 µg per lane. Predicted band size : 56 kDa
Immunocytochemistry - Anti-Angiopoietin 2 antibody (ab125692)
Immunohistochemistry of Angiopoietin 2 in mouse liver tissue with ab125692 antibody at 2.5 ug/mL.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"