Anti-Angiotensin Converting Enzyme 2 antibody [EPR4435(2)] (ab108252)


  • Product nameAnti-Angiotensin Converting Enzyme 2 antibody [EPR4435(2)]
    See all Angiotensin Converting Enzyme 2 primary antibodies
  • Description
    Rabbit monoclonal [EPR4435(2)] to Angiotensin Converting Enzyme 2
  • Tested applicationsSuitable for: WB, IP, IHC-P, ICCmore details
    Unsuitable for: Flow Cyt
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues in the extracellular domain of Human Angiotensin Converting Enzyme 2.

  • Positive control
    • Fetal kidney and Human testis lysate; Human kidney tissue; Human testis tissue
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab108252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 92 kDa.
IP 1/10 - 1/100.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC 1/50 - 1/100.
  • Application notesIs unsuitable for Flow Cyt.
  • Target

    • FunctionCarboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
    • Tissue specificityExpressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
    • Sequence similaritiesBelongs to the peptidase M2 family.
    • Post-translational
      N-glycosylation on Asn-90 may limit SARS infectivity.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACE 2 antibody
      • ACE related carboxypeptidase antibody
      • ACE-related carboxypeptidase antibody
      • ACE2 antibody
      • ACE2_HUMAN antibody
      • ACEH antibody
      • Angiotensin converting enzyme 2 antibody
      • Angiotensin converting enzyme homolog antibody
      • Angiotensin converting enzyme like protein antibody
      • Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody
      • Angiotensin I converting enzyme 2 antibody
      • Angiotensin-converting enzyme homolog antibody
      • DKFZP434A014 antibody
      • EC 3.4.17 antibody
      • metalloprotease MPROT 15 antibody
      • Metalloprotease MPROT15 antibody
      • OTTHUMP00000022963 antibody
      • Processed angiotensin-converting enzyme 2 antibody
      see all

    Anti-Angiotensin Converting Enzyme 2 antibody [EPR4435(2)] images

    • All lanes : Anti-Angiotensin Converting Enzyme 2 antibody [EPR4435(2)] (ab108252) at 1/1000 dilution

      Lane 1 : Fetal kidney lysate
      Lane 2 : Human testis lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 92 kDa
    • ab108252, at 1/100 dilution, staining Angiotensin Converting Enzyme 2 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
    • ab108252, at 1/100 dilution, staining Angiotensin Converting Enzyme 2 in paraffin-embedded Human testis tissue by Immunohistochemistry

    References for Anti-Angiotensin Converting Enzyme 2 antibody [EPR4435(2)] (ab108252)

    This product has been referenced in:
    • Frantz ED  et al. Renin-angiotensin system blockers protect pancreatic islets against diet-induced obesity and insulin resistance in mice. PLoS One 8:e67192 (2013). WB . Read more (PubMed: 23894285) »

    See 1 Publication for this product

    Product Wall

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    The link to our list of buffer solutions and their composition is:

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