Anti-Angiotensin Converting Enzyme 2 antibody - N-terminal (ab76526)

Overview

  • Product nameAnti-Angiotensin Converting Enzyme 2 antibody - N-terminal
    See all Angiotensin Converting Enzyme 2 primary antibodies
  • Description
    Rabbit polyclonal to Angiotensin Converting Enzyme 2 - N-terminal
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide selected from the N-terminal region of human ACE2 conjugated to KLH

  • Positive control
    • WB: K562 cell line lysate IHC: Human cancer tissue (hepatocarcinoma) and human testis tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab76526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/250. Predicted molecular weight: 92 kDa.
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • FunctionCarboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
  • Tissue specificityExpressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
  • Sequence similaritiesBelongs to the peptidase M2 family.
  • Post-translational
    modifications
    N-glycosylation on Asn-90 may limit SARS infectivity.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACE 2 antibody
    • ACE related carboxypeptidase antibody
    • ACE-related carboxypeptidase antibody
    • ACE2 antibody
    • ACE2_HUMAN antibody
    • ACEH antibody
    • Angiotensin converting enzyme 2 antibody
    • Angiotensin converting enzyme homolog antibody
    • Angiotensin converting enzyme like protein antibody
    • Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody
    • Angiotensin I converting enzyme 2 antibody
    • Angiotensin-converting enzyme homolog antibody
    • DKFZP434A014 antibody
    • EC 3.4.17 antibody
    • metalloprotease MPROT 15 antibody
    • Metalloprotease MPROT15 antibody
    • OTTHUMP00000022963 antibody
    • Processed angiotensin-converting enzyme 2 antibody
    see all

Anti-Angiotensin Converting Enzyme 2 antibody - N-terminal images

  • Anti-Angiotensin Converting Enzyme 2 antibody - N-terminal (ab76526) at 1/60 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 92 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human cancer tissue (hepatocarcinoma), stained with ab76526, at 1/50 dilution, using a peroxidase-conjugated secondary antibody and AEC staining.
  • Formalin-fixed and paraffin-embedded human testis tissue, stained with ab76526, at 1/50 dilution, using a peroxidase-conjugated secondary antibody and DAB staining.

References for Anti-Angiotensin Converting Enzyme 2 antibody - N-terminal (ab76526)

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you for your telephone call. As discussed, I am sorry that as we carry over 70,000 products, it is not feasible for us to keep small sample sizes of our products to send to customers. We are happy to reassure our customers that all of our...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"