Overview

  • Product name
  • Description
    Rabbit polyclonal to ANKRD1
  • Specificity
    Detects endogenous levels of total ANKRD1 protein.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide (Human) from an internal region

  • Positive control
    • COLO205 cell extract

Properties

Applications

Our Abpromise guarantee covers the use of ab64963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
ELISA 1/20000.

Target

  • Function
    May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
  • Tissue specificity
    Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
  • Involvement in disease
    Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
  • Sequence similarities
    Contains 5 ANK repeats.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALRP antibody
    • ANKR1_HUMAN antibody
    • ANKRD 1 antibody
    • ANKRD1 antibody
    • Ankyrin repeat domain 1 (cardiac muscle) antibody
    • Ankyrin repeat domain containing protein 1 antibody
    • Ankyrin repeat domain-containing protein 1 antibody
    • bA320F15.2 antibody
    • C 193 antibody
    • C193 antibody
    • Cardiac ankyrin repeat protein antibody
    • CARP antibody
    • CVARP antibody
    • Cytokine inducible nuclear protein antibody
    • Cytokine-inducible gene C-193 protein antibody
    • Cytokine-inducible nuclear protein antibody
    • HA1A2 antibody
    • Liver ankyrin repeat domain 1 antibody
    • MCARP antibody
    • OTTHUMP00000020084 antibody
    see all

Images

  • All lanes : Anti-ANKRD1 antibody (ab64963) at 1/500 dilution

    Lane 1 : COLO205 cell extract
    Lane 2 : COLO205 cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 36 kDa
    Observed band size : 36 kDa

References

This product has been referenced in:
  • Band M  et al. The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi. J Mol Evol 70:1-12 (2010). WB ; Rat, Other . Read more (PubMed: 19967343) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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