Overview

  • Product nameAnti-ANKRD15 antibody
    See all ANKRD15 primary antibodies
  • Description
    Mouse monoclonal to ANKRD15
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MGSLNSQLIS TLSSINSVMK SASTEELRNP DFQKTSLGKI TGNYLGYTCK CGGLQSGSPL SSQTSQPEQE VGTSEGKPIS SLDAFPTQEG TLSPVNLTDD , corresponding to amino acids 701-800 of Human ANKRD15

Properties

Applications

Our Abpromise guarantee covers the use of ab57391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
    • Tissue specificityWidely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.
    • Involvement in diseaseDefects in KANK1 are the cause of cerebral palsy spastic quadriplegic type 2 (CPSQ2) [MIM:612900]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly.
    • Sequence similaritiesContains 5 ANK repeats.
    • Cellular localizationCell projection > ruffle membrane. Colocalizes with KIF21A in membrane ruffles; Cytoplasm. Nucleus. Cell projection > ruffle membrane. Shuttles between the cytoplasm and nucleus and Cytoplasm. Nucleus. Shuttles between the cytoplasm and nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • ANKRD 15 antibody
      • Ankyrin repeat domain 15 antibody
      • Ankyrin repeat domain containing protein 15 antibody
      • Ankyrin repeat domain-containing protein 15 antibody
      • DKFZp451G231 antibody
      • KANK antibody
      • KANK1 antibody
      • KANK1_HUMAN antibody
      • KIAA0172 antibody
      • Kidney ankyrin repeat containing protein antibody
      • Kidney ankyrin repeat-containing protein antibody
      • KN motif and ankyrin repeat domain-containing protein 1 antibody
      • MGC43128 antibody
      see all

    Anti-ANKRD15 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57391 ANKRD15 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    References for Anti-ANKRD15 antibody (ab57391)

    ab57391 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57391.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"