Overview

  • Product nameAnti-ANKRD17 antibody
    See all ANKRD17 primary antibodies
  • Description
    Rabbit polyclonal to ANKRD17
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 1550-1600 of Human ANKRD17 (NP_115593.3, GeneID 26057).

  • Positive control
    • Human Controls: Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Skin Basal Cell Carcinoma, Testicular Seminoma
  • General notesImmunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

Properties

Applications

Our Abpromise guarantee covers the use of ab105112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Target

  • FunctionCould play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesContains 25 ANK repeats.
    Contains 1 KH domain.
  • Post-translational
    modifications
    Phosphorylated by CDK2.
  • Cellular localizationCytoplasm. Nucleus. Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANKRD 17 antibody
    • ANKRD17 antibody
    • Ankyrin repeat domain protein 17 antibody
    • Ankyrin repeat domain-containing protein 17 antibody
    • ANR17_HUMAN antibody
    • FLJ22206 antibody
    • Gene trap ankyrin repeat antibody
    • Gene trap ankyrin repeat protein antibody
    • GTAR antibody
    • KIAA0697 antibody
    • NY BR 16 antibody
    • NY-BR-16 antibody
    • Serologically defined breast cancer antigen NY-BR-16 antibody
    see all

Anti-ANKRD17 antibody images

  • ab105112 at 1/250 dilution staining ANKRD17 in Human breast carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining
  • ab105112 at 1/250 dilution staining ANKRD17 in Human prostate carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

References for Anti-ANKRD17 antibody (ab105112)

ab105112 has not yet been referenced specifically in any publications.

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