Human Predicted to work with:
Recombinant fragment, corresponding to amino acids 177-329 of Human Annexin II (NM_001002857).
WB: SW480 and MDA-MB-231 cell lysates
IHC-P: Human colon carcinoma tissue
Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
Belongs to the annexin family. Contains 4 annexin repeats.
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
Secreted > extracellular space > extracellular matrix > basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.