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Anti-Annexin A2 antibody [M298] - C-terminal (ab86709)

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Overview

  • Product nameAnti-Annexin A2 antibody [M298] - C-terminalSee all Annexin A2 primary antibodies ...
  • Description
    Mouse monoclonal [M298] to Annexin A2 - C-terminal
  • Tested applicationsWB, IP, ELISA more details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Recombinant fragment, corresponding to the C-terminal region of Rat Annexin II

  • Positive controlPC12 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab86709 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/1000. Detects a band of approximately 36 kDa.
IP IP: 1/50.
ELISA ELISA: 1/2000.

Target

  • FunctionCalcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
  • Sequence similaritiesBelongs to the annexin family.
    Contains 4 annexin repeats.
  • DomainA pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Post-translational
    modifications    Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
    ISGylated.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

    • Target information above from: UniProt accession P07355 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Annexin A2 antibodyAnnexin II antibodyAnnexin-2 antibody
        ANX 2 antibodyANX2 antibodyANX2L4 antibodyANXA2 antibodyANXA2_HUMAN antibodyarylsulfatase B antibodyCAL1H antibodyCalpactin I heavy chain antibodycalpactin I heavy polypeptide (p36) antibodyCalpactin-1 heavy chain antibodychromobindin 8 antibodyChromobindin-8 antibodyLIP2 antibodyLipocortin II antibodyLPC2 antibodyLPC2D antibodyP36 antibodyP36 protein antibodyPAP-IV antibodyplacental anticoagulant protein IV antibodyProtein I antibody
      see all

    Anti-Annexin A2 antibody [M298] - C-terminal images

    • Western blot - Annexin II antibody [M298] - Carboxyterminal end (ab86709)
      Western blot - Annexin II antibody [M298] - Carboxyterminal end (ab86709)
      Lane 1 : Anti-Annexin A2 antibody [M298] - C-terminal (ab86709) at 1/250 dilution
      Lane 2 : Anti-Annexin A2 antibody [M298] - C-terminal (ab86709) at 1/1000 dilution

      Lane 1 : Rat PC12 cell lysate
      Lane 2 : Rat PC12 cell lysate


      Observed band size : 36 kDa (why is the actual band size different from the predicted?)

    References for Anti-Annexin A2 antibody [M298] - C-terminal (ab86709)

    ab86709 has not yet been referenced specifically in any publications.

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