• Product nameAnti-ANP antibody [M622709]
    See all ANP primary antibodies
  • Description
    Mouse monoclonal [M622709] to ANP
  • SpecificityAffinity Constant: 2.2 x 1010 L/M
  • Tested applicationsSuitable for: Flow Cyt, RIA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Atrial Natriuretic Peptide whole molecule



Our Abpromise guarantee covers the use of ab2093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use at an assay dependent dilution (PMID 20080656).
    IHC-P: Use at an assay dependent dilution.
    RIA: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
    • Involvement in diseaseAtrial standstill 2
      Atrial fibrillation, familial, 6
    • Sequence similaritiesBelongs to the natriuretic peptide family.
    • Post-translational
      Cleaved by CORIN upon secretion to produce the functional hormone.
      Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • ANF antibody
      • ANF_HUMAN antibody
      • ANP antibody
      • ATFB6 antibody
      • Atrial natriuretic factor antibody
      • Atrial natriuretic peptide antibody
      • Atriopeptin antibody
      • Cardiodilatin antibody
      • Cardiodilatin-related peptide antibody
      • Cardionatrin antibody
      • CDD ANF antibody
      • CDD antibody
      • CDD-ANF antibody
      • CDP antibody
      • Natriuretic peptide A antibody
      • Natriuretic peptide precursor A antibody
      • NPPA antibody
      • PND antibody
      • Prepronatriodilatin antibody
      see all

    References for Anti-ANP antibody [M622709] (ab2093)

    This product has been referenced in:
    • Therrien JP  et al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt ; Human . Read more (PubMed: 20080656) »

    See 1 Publication for this product

    Product Wall

    Abcam has not validated the combination of species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Mouse Tissue sections (Heart tissue including atrium)
    Antigen retrieval step None
    Permeabilization No
    Specification Heart tissue including atrium
    Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2000µg/mL · Temperature: 21D°C
    Fixative Formaldehyde

    Dr. Isabelle Miletich

    Verified customer

    Submitted Nov 04 2016

    Thank you for contacting us.

    I have attached the CoCs for ab14319, Anti-Urodilatin antibody and for ab2093 Anti-ANP antibody [M622709] as well the SDS for ab2093. I have also asked our documents team to create the SDS for ab14319. This w...

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    Thank you for your enquiry. Unfortunately, we do not have the protein that was used to make this antibody in our catalogue and I am afraid that I do not know if it is commercially available. I am sorry I can't be of more assistance in this occas...

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    Thank you for your enquiry. ab2093 was generated using Atrial Natriuretic Peptide whole molecule as the immunogen. The peptide sequence has accession number: CAA25700 and the following sequence: MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHL...

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    Clone M622709 is subtype IgG1. The approximate molecular weight of IgG1 is 148,000 daltons. This antibody has only been tested for application in Immunohistochemistry (Formalin-fixed paraffin-embedded sections)and Radioimmunoassay.

    Thank you for your enquiry and your interest in our products. As my colleagues possibly explained to you over the telephone, this antibody has not been tested for Western blot application. According to the datasheet, ab2093 recognizes the native for...

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