Anti-Anthrax EF antibody (ab21267)

Overview

  • Product nameAnti-Anthrax EF antibody
  • Description
    Rabbit polyclonal to Anthrax EF
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with Bacillus anthracis. Not yet tested in other species.
  • Immunogen

    Synthetic peptide corresponding to 16 amino acids near the carboxy terminus of Anthrax Edema Factor.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab21267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 1 µg/ml. Note: at this concentration ab21267 will detect 10 ng of free peptide.

Target

  • RelevanceAnthrax infection is initiated by inhalation, ingestion or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF) and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++ dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system.
  • Alternative names
    • Adenylyl cyclase antibody
    • Bacillus anthracis EF antibody
    • Cya antibody
    • Edema factor antibody
    • EF antibody
    see all

References for Anti-Anthrax EF antibody (ab21267)

ab21267 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry. Unfortunately, we do not have any anthrax PA antigen available in our catalog. I would like to recommend checking the Biocompare website which has an excellent antibody search facility that includes many suppliers. The...

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Thank you for contacting us. Our antibody ab21267 is against Anthrax EF, it is not an anti-Anthrax PA. We have a pair of antibodies anti-Anthrax PA for sELISA : - ab8240 that can be used as capture antibody - ab1990 that can be used as detect...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"