Overview

  • Product name
    Anti-Antithrombin III antibody
    See all Antithrombin III primary antibodies
  • Description
    Goat polyclonal to Antithrombin III
  • Tested applications
    Suitable for: IP, Immunodiffusionmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Sheep, Cow, Orangutan
  • Immunogen

    Full length native protein (purified) corresponding to Human Antithrombin III aa 33-464. (Isolated and highly purified from pooled plasma).
    Sequence:

    HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWE LSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQ QLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDK SLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITD VIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSAS MMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELT PEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSK LPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRV TFKANRPFLVFIREVPLNTIIFMGRVANPCVK


    Database link: P01008

  • Positive control
    • Human plasma.
  • General notes

    The amount of Antithrombin III precipitated by 1 ml antiserum is about 1.75 U. One unit is the average amount of Antithrombin III in normal plasma which corresponds to 0.15 mg/ml.

Properties

  • Form
    Lyophilised:Reconstitute the lyophilized antiserum by adding 1 ml sterile distilled water. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Diluted stock solutions should be used immediately and not be frozen.
  • Storage buffer
    No preservative added. No foreign proteins added.
  • Concentration information loading...
  • Purity
    Whole antiserum
  • Purification notes
    Delipidated, heat inactivated, stable whole antiserum. Total protein and IgG concentrations in ab182962 are comparable to those of pooled normal goat serum.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab182962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
Immunodiffusion Use at an assay dependent concentration.

Precipitin titre 1/32 when tested in agar-block immunodiffusion titration against normal Human plasma.

Target

  • Function
    Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
  • Tissue specificity
    Found in plasma.
  • Involvement in disease
    Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
  • Sequence similarities
    Belongs to the serpin family.
  • Post-translational
    modifications
    Phosphorylation sites are present in the extracelllular medium.
  • Cellular localization
    Secreted > extracellular space.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANT3_HUMAN antibody
    • Antithrombin antibody
    • Antithrombin III antibody
    • Antithrombin-III antibody
    • AntithrombinIII antibody
    • AT 3 antibody
    • AT III antibody
    • AT3 antibody
    • AT3D antibody
    • ATIII antibody
    • Heparin cofactor I antibody
    • MGC22579 antibody
    • Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody
    • Serine cysteine proteinase inhibitor clade C member 1 antibody
    • Serine proteinase inhibitor clade C member 1 antibody
    • Serpin C1 antibody
    • Serpin family C member 1 antibody
    • Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody
    • SERPINC1 antibody
    • THPH7 antibody
    see all

References

ab182962 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab182962.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up