• Product nameAnti-ANTXR2 antibody
    See all ANTXR2 primary antibodies
  • Description
    Mouse polyclonal to ANTXR2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    ANTXR2 (NP_477520.2, 1 a.a. ~ 488 a.a) human protein.

  • Positive control
    • ANTXR2 transfected 293T lysate and human kidnaey tissue lysate.


Associated products


Our Abpromise guarantee covers the use of ab70499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 54 kDa (predicted molecular weight: 54 kDa).


  • FunctionNecessary for cellular interactions with laminin and the extracellular matrix.
  • Tissue specificityExpressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • Involvement in diseaseDefects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH) [MIM:236490]. This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures.
    Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF) [MIM:228600]. JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility.
  • Sequence similaritiesBelongs to the ATR family.
    Contains 1 VWFA domain.
  • DomainBinding to PA seems to be effected through the VWA domain.
  • Cellular localizationSecreted; Cell membrane. Expressed at the cell surface and Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2310046B19Rik antibody
    • Anthrax toxin receptor 2 antibody
    • ANTR2_HUMAN antibody
    • Antxr2 antibody
    • AW561899 antibody
    • Capillary morphogenesis gene 2 protein antibody
    • Capillary morphogenesis protein 2 antibody
    • CMG 2 antibody
    • CMG-2 antibody
    • CMG2 antibody
    • FLJ31074 antibody
    • HFS antibody
    • ISH antibody
    • JHF antibody
    • MGC111533 antibody
    • MGC45856 antibody
    see all

Anti-ANTXR2 antibody images

  • All lanes : Anti-ANTXR2 antibody (ab70499) at 1/500 dilution

    Lane 1 : ANTXR2 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

References for Anti-ANTXR2 antibody (ab70499)

This product has been referenced in:
  • Xi Y  et al. Improving the anti-toxin abilities of the CMG2-Fc fusion protein with the aid of computational design. PLoS One 9:e104674 (2014). WB . Read more (PubMed: 25101992) »

See 1 Publication for this product

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