Anti-AP2 beta antibody (ab126207)
Key features and details
- Rabbit polyclonal to AP2 beta
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AP2 beta antibody -
Description
Rabbit polyclonal to AP2 beta -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chicken, Cow, Dog, Xenopus laevis, Zebrafish -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 232-423 of Human AP2 beta (Q92481).
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Positive control
- MCF7 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126207 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 50 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 50 kDa. |
Target
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Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. -
Involvement in disease
Defects in TFAP2B are the cause of Char syndrome (CHAR) [MIM:169100]. CHAR is an autosomal dominant disorder characterized by patent ductus arteriosus (PDA), facial dysmorphism and hand anomalies. -
Sequence similarities
Belongs to the AP-2 family. -
Post-translational
modificationsSumoylated on Lys-21; which inhibits transcriptional activity. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 395713 Chicken
- Entrez Gene: 540867 Cow
- Entrez Gene: 403463 Dog
- Entrez Gene: 7021 Human
- Entrez Gene: 447525 Xenopus laevis
- Entrez Gene: 550545 Zebrafish
- Omim: 601601 Human
- SwissProt: Q76HI7 Dog
see all -
Alternative names
- Activating enhancer binding protein 2 beta antibody
- Activating enhancer-binding protein 2-beta antibody
- AP 2B antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab126207 has not yet been referenced specifically in any publications.