The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Detects a band of approximately 130 kDa (predicted molecular weight: 130 kDa).
FunctionPart of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Tissue specificityPresent in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.
Sequence similaritiesBelongs to the adaptor complexes large subunit family. Contains 11 HEAT repeats.