Anti-AP3B2 antibody (ab14227)

Overview

• Product name
  Anti-AP3B2 antibody
  See all AP3B2 primary antibodies
• Description
  Chicken polyclonal to AP3B2
• Tested applications
  Suitable for: ICCmore details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide:

  SLLEENAEK AFYGSEEDEA KGAGSEETAA AAAPSRKPYV MDPDHRLLLR NTKPLLQSRSA AVVMAVAQLYFH LAPKAEVGVIAK ALVRLLRS

  , corresponding to amino acids 259-350 of Human AP3B2.

  Run BLAST with Run BLAST with

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  Preservative: None
  Constituents: PBS
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Clonality
  Polyclonal
• Isotype
  IgY
• Research areas
  • Neuroscience
  • Neurotransmission
  • Intracellular Signaling
  • Adapters

Applications

Target

• Function
  Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
• Tissue specificity
  Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression).
• Sequence similarities
  Belongs to the adaptor complexes large subunit family.
• Developmental stage
  Expressed from early in development through adulthood.
• Cellular localization
  Golgi apparatus. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Golgi apparatus. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

• Target information above from: UniProt accession Q13367 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 8120 Human
  • Entrez Gene: 11775 Mouse
  • Entrez Gene: 308777 Rat
  • Omim: 602166 Human
  • SwissProt: Q13367 Human
  • SwissProt: Q9JME5 Mouse
  • Unigene: 199593 Human
  • Unigene: 322894 Mouse
• Alternative names
  • Adapter-related protein complex 3 subunit beta-2 antibody
  • Adaptor protein complex AP-3 subunit beta-2 antibody
  • Adaptor related protein complex 3 beta 2 subunit antibody

  • AP 3 complex subunit beta 2 antibody
  • AP-3 complex subunit beta-2 antibody
  • AP3B2 antibody
  • AP3B2_HUMAN antibody
  • beta NAP antibody
  • Beta-3B-adaptin antibody
  • Beta3B adaptin antibody
  • Beta3b antibody
  • Clathrin assembly protein complex 3 beta 2 large chain antibody
  • Clathrin assembly protein complex 3 beta-2 large chain antibody
  • NAPTB antibody
  • Neuron specific vesicle coat protein and cerebellar degeneration antigen antibody
  • Neuron-specific vesicle coat protein beta-NAP antibody
  • Neuronal adaptin like protein beta subunit antibody

  see all

Protocols

• Immunocytochemistry & immunofluorescence protocols