Overview

  • Product name
  • Description
    Rabbit polyclonal to AP3B2
  • Specificity
    By Western blot this antibody detects a ~119-130 kDa protein representing AP3B2 from brain samples.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human AP3B2 aa 260-274. Mouse sequence is LLEENPEKAFYGSEE
    Sequence:

    LLEENAEKAFYGSEE


    (Peptide available as ab48404)

  • Positive control
    • Human brain samples.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.05% Sodium Azide
    Constituents: 1mg/ml BSA
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab48269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 119-130 kDa (predicted molecular weight: 119 kDa).Can be blocked with Mouse AP3B2 peptide (ab48404).

Target

  • Function
    Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
  • Tissue specificity
    Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression).
  • Sequence similarities
    Belongs to the adaptor complexes large subunit family.
  • Developmental stage
    Expressed from early in development through adulthood.
  • Cellular localization
    Golgi apparatus. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Golgi apparatus. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adapter-related protein complex 3 subunit beta-2 antibody
    • Adaptor protein complex AP-3 subunit beta-2 antibody
    • Adaptor related protein complex 3 beta 2 subunit antibody
    • AP 3 complex subunit beta 2 antibody
    • AP-3 complex subunit beta-2 antibody
    • AP3B2 antibody
    • AP3B2_HUMAN antibody
    • beta NAP antibody
    • Beta-3B-adaptin antibody
    • Beta3B adaptin antibody
    • Beta3b antibody
    • Clathrin assembly protein complex 3 beta 2 large chain antibody
    • Clathrin assembly protein complex 3 beta-2 large chain antibody
    • NAPTB antibody
    • Neuron specific vesicle coat protein and cerebellar degeneration antigen antibody
    • Neuron-specific vesicle coat protein beta-NAP antibody
    • Neuronal adaptin like protein beta subunit antibody
    see all

Images

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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