Overview

  • Product name
    Anti-AP4E1 antibody
  • Description
    Rabbit polyclonal to AP4E1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen, corresponding to amino acids 941-1056 of Human AP4E1.

  • Positive control
    • Human pancreas tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab122740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
  • Tissue specificity
    Widely expressed.
  • Involvement in disease
    Defects in AP4E1 are the cause of cerebral palsy spastic quadriplegic type 4 (CPSQ4) [MIM:613744]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication.
  • Sequence similarities
    Belongs to the adaptor complexes large subunit family.
  • Cellular localization
    Golgi apparatus > trans-Golgi network. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adapter-related protein complex 4 subunit epsilon-1 antibody
    • Adaptor related protein complex 4 epsilon 1 subunit antibody
    • Adaptor related protein complex AP 4 epsilon antibody
    • AP-4 adapter complex subunit epsilon antibody
    • AP-4 complex subunit epsilon-1 antibody
    • Ap4e1 antibody
    • AP4E1_HUMAN antibody
    • CPSQ4 antibody
    • Epsilon subunit of AP-4 antibody
    • Epsilon-adaptin antibody
    see all

Images

  • ab122740 at 1/200 dilution staining AP4E1 in Paraffin-embedded Human pancreas tissue by Immunohistochemistry.

References

ab122740 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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