Overview

  • Product nameAnti-AP4E1 antibody
    See all AP4E1 primary antibodies
  • Description
    Rabbit polyclonal to AP4E1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 306-408 of Human AP4E1.

  • Positive control
    • Human small intestine tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab122753 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionSubunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in AP4E1 are the cause of cerebral palsy spastic quadriplegic type 4 (CPSQ4) [MIM:613744]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication.
  • Sequence similaritiesBelongs to the adaptor complexes large subunit family.
  • Cellular localizationGolgi apparatus > trans-Golgi network. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adapter-related protein complex 4 subunit epsilon-1 antibody
    • Adaptor related protein complex 4 epsilon 1 subunit antibody
    • Adaptor related protein complex AP 4 epsilon antibody
    • AP-4 adapter complex subunit epsilon antibody
    • AP-4 complex subunit epsilon-1 antibody
    • Ap4e1 antibody
    • AP4E1_HUMAN antibody
    • CPSQ4 antibody
    • Epsilon subunit of AP-4 antibody
    • Epsilon-adaptin antibody
    see all

Anti-AP4E1 antibody images

  • ab122753 at 1/50 dilution, staining AP4E1 in Paraffin-embedded Human small intestine tissue by Immunohistochemistry.

References for Anti-AP4E1 antibody (ab122753)

ab122753 has not yet been referenced specifically in any publications.

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