Overview

  • Product nameAnti-AP4M1 antibody
    See all AP4M1 primary antibodies
  • Description
    Mouse monoclonal to AP4M1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: AELAEGALRW DLPRVQGGSQ LSGLFQMDVP GPPGPPSHGL STSASPLGLG PASLSFELPR HTCSGLQVRF LRLAFRPCGN ANPHKWVRHL SHSDAYVIRI , corresponding to amino acids 354-454 of Human AP4M1

Properties

Applications

Our Abpromise guarantee covers the use of ab56473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSubunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
    • Tissue specificityUbiquitous. Highly expressed in testis and lowly expressed in brain and lung.
    • Involvement in diseaseDefects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3) [MIM:612936]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture.
    • Sequence similaritiesBelongs to the adaptor complexes medium subunit family.
      Contains 1 MHD (mu homology) domain.
    • DomainInteracts specifically with tyrosine-based sorting signals.
    • Cellular localizationGolgi apparatus > trans-Golgi network. Membrane > coated pit. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • Adapter-related protein complex 4 mu-1 subunit antibody
      • Adaptor related protein complex 4 mu 1 subunit antibody
      • Adaptor related protein complex AP 4 mu4 subunit antibody
      • Adaptor related protein complex AP4 mu4 subunit antibody
      • Adaptor-related protein complex AP-4, mu 1 antibody
      • AP 4 adapter complex mu subunit antibody
      • AP 4 complex subunit mu 1 antibody
      • AP-4 adapter complex mu subunit antibody
      • AP-4 complex subunit mu-1 antibody
      • AP4 adapter complex mu subunit antibody
      • AP4 complex subunit mu 1 antibody
      • AP4M1 antibody
      • AP4M1_HUMAN antibody
      • Ap4m4 antibody
      • CPSQ3 antibody
      • MU 4 antibody
      • Mu adaptin related protein 2 antibody
      • MU ARP2 antibody
      • Mu subunit of AP 4 antibody
      • Mu subunit of AP-4 antibody
      • Mu-adaptin-related protein 2 antibody
      • mu-ARP2 antibody
      • mu4 antibody
      • Mu4-adaptin antibody
      • MUARP 2 antibody
      • MUARP2 antibody
      • SPG50 antibody
      see all

    Anti-AP4M1 antibody images



    • Predicted band size : 50 kDa
      AP4M1 antibody (ab56473) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-AP4M1 antibody (ab56473)

    ab56473 has not yet been referenced specifically in any publications.

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