Overview

  • Product name
  • Description
    Rabbit polyclonal to APBA1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic 12 amino acid peptide near the center of the mouse APBA1

  • Positive control
    • Mouse spleen tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab69991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 93 kDa).

Target

  • Function
    Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
  • Tissue specificity
    Brain and spinal cord.
  • Sequence similarities
    Contains 2 PDZ (DHR) domains.
    Contains 1 PID domain.
  • Domain
    Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adapter protein X11 alpha antibody
    • Adapter protein X11alpha antibody
    • Amyloid beta A4 precursor protein-binding family A member 1 antibody
    • Apba1 antibody
    • APBA1_HUMAN antibody
    • Mint 1 antibody
    • Mint-1 antibody
    • Neuron specific X11 protein antibody
    • Neuron-specific X11 protein antibody
    • Neuronal Munc18 1 interacting protein 1 antibody
    • Neuronal Munc18-1-interacting protein 1 antibody
    • UROP11 antibody
    • x11 antibody
    • X11alpha antibody
    see all

Images

  • Lane 1 : Anti-APBA1 antibody (ab69991) at 1 µg/ml
    Lane 2 : Anti-APBA1 antibody (ab69991) at 2 µg/ml

    Lane 1 : Mouse spleen tissue lysate
    Lane 2 : Mouse spleen tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 93 kDa
    Observed band size : 39 kDa (why is the actual band size different from the predicted?)

References

ab69991 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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