Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Cell Biology >> Cell Cycle >> Cell Division >> Spindle
Overview
Product name
Anti-APC antibody [T45]
See all APC products (11) ...
Description
Rat monoclonal [T45] to APC
Specificity
This antibody is specific for APC proteins.
Tested applications
WB, ELISA, ICC/IFmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Recombinant full length APC protein (Mouse)
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
T45
Isotype
IgG
Research areas
Cardiovascular >> Heart >> Cardiogenesis >> Transcription factors/regulators
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> PTC & Wnt pathway
Cancer >> Cell cycle >> Cell division
Stem Cells >> Signaling Pathways >> Wnt >> Cytoplasmic
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Neuroscience >> Cell Type Marker >> Glia marker >> Oligodendrocyte marker
Cell Biology >> Cell Cycle >> Cell Division >> Spindle
Applications
Show applications key
Our Abpromise guarantee covers the use of ab45764 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000Predicted molecular weight: 312 kDa.
ELISA
ELISA: 1/2000 - 1/5000.ELISA: 1/2000 - 1/5000.
ICC/IF: Use at an assay dependent dilution.
Target
Relevance
Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regulates ß-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Cellular localization
Cell junction; adherens junction
Alternative names
- Adenomatous Polyposis Coli antibody
- Adenomatous Polyposis Coli antibody
- APC antibody
see all
Database links
- Entrez Gene: 11789 Mouse
- SwissProt: Q61315 Mouse
References for Anti-APC antibody [T45] (ab45764)
ab45764 has not yet been referenced specifically in any publications.
Publishing research using ab45764? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"