Overview

  • Product name
  • Description
    Rabbit polyclonal to Apc10
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-135 of Human Apc10 (Q9UM13).

  • Positive control
    • MCF7 whole cell lysate.
  • General notes
    Keep as concentrated solution.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 21 kDa.

Target

  • Function
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the APC10 family.
    Contains 1 DOC domain.
  • Information by UniProt
  • Database links
  • Form
    It localises to Cytosol and nucleoplasm.
  • Alternative names
    • ANAPC 10 antibody
    • anapc10 antibody
    • Anaphase promoting complex 10 antibody
    • Anaphase promoting complex subunit 10 antibody
    • Anaphase-promoting complex subunit 10 antibody
    • Apc 10 antibody
    • APC10 antibody
    • APC10_HUMAN antibody
    • Cyclosome subunit 10 antibody
    • DKFZP564L0562 antibody
    • Doc 1 antibody
    • Doc1 antibody
    • Doc1, S. cerevisiae, homolog of antibody
    • OTTHUMP00000220297 antibody
    • OTTHUMP00000220298 antibody
    • OTTHUMP00000220299 antibody
    • OTTHUMP00000220300 antibody
    • OTTHUMP00000220303 antibody
    see all

Images

  • Anti-Apc10 antibody (ab126204) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg

    Predicted band size : 21 kDa

References

This product has been referenced in:
  • Sako K  et al. Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C. Nat Commun 5:3667 (2014). Read more (PubMed: 24770399) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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