Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
    • Tissue specificityExpressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesBelongs to the RING-box family.
      Contains 1 RING-type zinc finger.
    • DomainThe RING-type zinc finger domain coordinates an additional third zinc ion.
    • Post-translational
      modifications
      Auto-ubiquitinated.
    • Cellular localizationCytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • ANAPC 11 antibody
      • ANAPC11 antibody
      • Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
      • Anaphase promoting complex subunit 11 antibody
      • Anaphase promoting complex subunit 11 homolog (yeast) antibody
      • Anaphase promoting complex subunit 11 homolog antibody
      • Anaphase-promoting complex subunit 11 antibody
      • Apc 11 antibody
      • Apc 11p antibody
      • APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody
      • APC11 anaphase promoting complex subunit 11 homolog antibody
      • APC11 antibody
      • APC11_HUMAN antibody
      • Apc11p antibody
      • Cyclosome subunit 11 antibody
      • Hepatocellular carcinoma associated RING finger protein antibody
      • Hepatocellular carcinoma-associated RING finger protein antibody
      • HSPC 214 antibody
      • HSPC214 antibody
      • MGC882 antibody
      • Yeast APC 11 homolog antibody
      • Yeast APC11 homolog antibody
      see all

    Anti-Apc11 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57158 Apc11 antibody at 1ug/ml. Predicted band size of immunogen is 31 kDa

    References for Anti-Apc11 antibody (ab57158)

    ab57158 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"