Overview

  • Product name
    Anti-Apc11 antibody [AX2.1]
    See all Apc11 primary antibodies
  • Description
    Mouse monoclonal [AX2.1] to Apc11
  • Host species
    Mouse
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human, Xenopus laevis
  • Immunogen

    Synthetic peptide spanning the carboxy region of APC11.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Clonality
    Monoclonal
  • Clone number
    AX2.1
  • Myeloma
    Sp2/0-Ag14
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab78092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 10 kDa.

Target

  • Function
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
  • Tissue specificity
    Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the RING-box family.
    Contains 1 RING-type zinc finger.
  • Domain
    The RING-type zinc finger domain coordinates an additional third zinc ion.
  • Post-translational
    modifications
    Auto-ubiquitinated.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANAPC 11 antibody
    • ANAPC11 antibody
    • Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
    • Anaphase promoting complex subunit 11 antibody
    • Anaphase promoting complex subunit 11 homolog (yeast) antibody
    • Anaphase promoting complex subunit 11 homolog antibody
    • Anaphase-promoting complex subunit 11 antibody
    • Apc 11 antibody
    • Apc 11p antibody
    • APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody
    • APC11 anaphase promoting complex subunit 11 homolog antibody
    • APC11 antibody
    • APC11_HUMAN antibody
    • Apc11p antibody
    • Cyclosome subunit 11 antibody
    • Hepatocellular carcinoma associated RING finger protein antibody
    • Hepatocellular carcinoma-associated RING finger protein antibody
    • HSPC 214 antibody
    • HSPC214 antibody
    • MGC882 antibody
    • Yeast APC 11 homolog antibody
    • Yeast APC11 homolog antibody
    see all

References

ab78092 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab78092.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up