Overview

  • Product nameAnti-Apc2 antibody
    See all Apc2 primary antibodies
  • Description
    Rabbit polyclonal to Apc2
  • Specificityab106600 is predicted to not cross-react with other Apc family members. At least four isoforms of Apc2 are known to exist.
  • Tested applicationsSuitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    18 amino acid peptide from near the center of Human Apc2 (BAA34611).

  • Positive control
    • HeLa cells and cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 244 kDa.
ICC Use a concentration of 5 µg/ml.

Target

  • FunctionComponent of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the cullin family.
  • Information by UniProt
  • Database links
  • Alternative names
    • anapc2 antibody
    • Anaphase promoting complex subunit 2 antibody
    • Anaphase-promoting complex subunit 2 antibody
    • ANC2_HUMAN antibody
    • APC2 antibody
    • Cyclosome subunit 2 antibody
    • KIAA1406 antibody
    • OTTHUMP00000022692 antibody
    • RP11 350O14.5 antibody
    see all

Anti-Apc2 antibody images

  • Immunofluorescence of Apc2 in HeLa cells with ab106600 at 20 ug/mL.

  • Lane 1 : Anti-Apc2 antibody (ab106600) at 1 µg/ml
    Lane 2 : Anti-Apc2 antibody (ab106600) at 2 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 244 kDa
  • Immunocytochemical analysis of ab106600 at 5 µg/ml in HeLa cells.

References for Anti-Apc2 antibody (ab106600)

ab106600 has not yet been referenced specifically in any publications.

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