Overview

  • Product nameAnti-Apc6 antibody
    See all Apc6 primary antibodies
  • Description
    Rabbit polyclonal to Apc6
  • Specificityab106495 is predicted not to cross-react with other APC family members.
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    An 18 amino acid synthetic peptide near the N terminus of Human Apc6 (NP_003894).

  • Positive control
    • Human liver tissue and lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab106495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 72 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionComponent of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the APC6/CDC16 family.
    Contains 7 TPR repeats.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
  • Cellular localizationCytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANAPC6 antibody
    • Anaphase promoting complex subunit 6 antibody
    • Anaphase-promoting complex subunit 6 antibody
    • Apc 6 antibody
    • APC6 antibody
    • CDC 16 antibody
    • CDC16 (cell division cycle 16 S. cerevisiae homolog) antibody
    • Cdc16 antibody
    • CDC16 homolog antibody
    • CDC16 protein antibody
    • CDC16_HUMAN antibody
    • CDC16Hs antibody
    • Cell division cycle 16 antibody
    • Cell division cycle 16 homolog antibody
    • Cell division cycle protein 16 homolog antibody
    • CUT9 antibody
    • Cyclosome subunit 6 antibody
    see all

Anti-Apc6 antibody images

  • Immunofluorescence of Apc6 in Human liver tissue with ab106495 at 20 ug/mL.

  • Lane 1 : Anti-Apc6 antibody (ab106495) at 1 µg/ml
    Lane 2 : Anti-Apc6 antibody (ab106495) at 2 µg/ml

    Lane 1 : Human liver tissue lysate
    Lane 2 : Human liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 72 kDa
  • ab106495, at 5 µg/ml, staining Apc6 in Human liver tissue by Immunohistochemistry.

References for Anti-Apc6 antibody (ab106495)

ab106495 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106495.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"