Overview

  • Product name
  • Description
    Mouse polyclonal to APCDD1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human APCDD1 protein (NP_694545.1).

  • Positive control
    • APCDD1 transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab73063 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 59 kDa.

Target

  • Function
    Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • Tissue specificity
    Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • Involvement in disease
    Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • Sequence similarities
    Belongs to the APCDD1 family.
  • Post-translational
    modifications
    N-Glycosylated.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenomatosis polyposis coli down regulated 1 antibody
    • Adenomatosis polyposis coli down regulated 1 protein antibody
    • Adenomatosis polyposis coli down-regulated 1 protein antibody
    • APCD1_HUMAN antibody
    • APCDD 1 antibody
    • APCDD1 antibody
    • B7323 antibody
    • DRAPC1 antibody
    • FP7019 antibody
    • HHS antibody
    • HTS antibody
    • hypoptrichosis simplex antibody
    • Protein APCDD1 antibody
    see all

Images

  • All lanes : Anti-APCDD1 antibody (ab73063) at 1 µg/ml

    Lane 1 : APCDD1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 59 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)

References

ab73063 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab73063.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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