Overview

  • Product name
    Anti-APCDD1 antibody - N-terminal
    See all APCDD1 primary antibodies
  • Description
    Rabbit polyclonal to APCDD1 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Xenopus laevis, Xenopus tropicalis
  • Immunogen

    Synthetic peptide within Human APCDD1 aa 68-98 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q8J025

  • Positive control
    • NCI-H292 cell lysate, Human liver tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab171851 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab171851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 59 kDa.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • Tissue specificity
    Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • Involvement in disease
    Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • Sequence similarities
    Belongs to the APCDD1 family.
  • Post-translational
    modifications
    N-Glycosylated.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • Adenomatosis polyposis coli down regulated 1 antibody
      • Adenomatosis polyposis coli down regulated 1 protein antibody
      • Adenomatosis polyposis coli down-regulated 1 protein antibody
      • APCD1_HUMAN antibody
      • APCDD 1 antibody
      • APCDD1 antibody
      • B7323 antibody
      • DRAPC1 antibody
      • FP7019 antibody
      • HHS antibody
      • HTS antibody
      • hypoptrichosis simplex antibody
      • Protein APCDD1 antibody
      see all

    Images

    • Anti-APCDD1 antibody - N-terminal (ab171851) at 1/100 dilution + NCI-H292 cell lysate at 35 µg

      Predicted band size: 59 kDa

    • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue, labeling APCDD1 with ab171851 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

    References

    This product has been referenced in:
    • Philippeos C  et al. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations. J Invest Dermatol 138:811-825 (2018). Read more (PubMed: 29391249) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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