Overview

  • Product name
    Anti-APEG1 antibody
  • Description
    Rabbit polyclonal to APEG1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant full length protein corresponding to amino acids 1-113 of Human APEG1 isoform 3 (AAH06346.1, Uniprot ID = Q15772-4)

  • Positive control
    • APEG1 transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab168746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 354 kDa.

Target

  • Function
    Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
  • Tissue specificity
    Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 2 fibronectin type-III domains.
    Contains 9 Ig-like (immunoglobulin-like) domains.
    Contains 2 protein kinase domains.
  • Post-translational
    modifications
    May be autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • APEG1 antibody
    • Aortic preferentially expressed gene 1 antibody
    • Aortic preferentially expressed protein 1 antibody
    • APEG 1 antibody
    • APEG-1 antibody
    • BPEG antibody
    • KIAA1297 antibody
    • MGC12676 antibody
    • Nuclear protein marker for differentiated aortic smooth muscle and down regulated with vascular injury antibody
    • OTTHUMP00000196351 antibody
    • OTTHUMP00000196352 antibody
    • OTTHUMP00000196353 antibody
    • speG antibody
    • SPEG complex locus antibody
    • SPEG_HUMAN antibody
    • SPEGalpha antibody
    • SPEGbeta antibody
    • striated muscle preferentially expressed protein kinase antibody
    • Striated muscle preferentially expressed protein kinase antibody
    see all

Images

  • All lanes : Anti-APEG1 antibody (ab168746) at 1 µg/ml

    Lane 1 : APEG1 transfected 293T cell lysate (12.70 KDa)
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

    Predicted band size: 354 kDa

References

ab168746 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab168746.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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