Overview

  • Product name
  • Description
    Rabbit polyclonal to Aph 1b
  • Specificity
    ab116657 does not cross react to other component of gamma secretase complex nor with other proteins.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Caenorhabditis elegans
  • Immunogen

    Synthetic peptide corresponding to a region near the C terminal amino acids 235-257 of Human Aph 1b.

  • General notes


    ab116657 also labels the anterior pharynx defective 1 homolog B in C. elegans.

Properties

Applications

Our Abpromise guarantee covers the use of ab116657 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 28 kDa.
ELISA 1/10000.

Target

  • Function
    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • Tissue specificity
    Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
  • Sequence similarities
    Belongs to the APH-1 family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Anterior pharynx defective 1 homolog B (C. elegans) antibody
    • Anterior pharynx defective 1 homolog B antibody
    • Anterior pharynx defective 1B like antibody
    • Anterior pharynx defective 1b short splicing variant antibody
    • APH 1B antibody
    • Aph 1beta antibody
    • APH-1b antibody
    • Aph-1beta antibody
    • Aph1 beta antibody
    • aph1b antibody
    • APH1B_HUMAN antibody
    • Aph1beta antibody
    • DKFZp564D0372 antibody
    • Gamma secretase subunit APH 1B antibody
    • Gamma secretase subunit APH1B antibody
    • Gamma secretase sununit antibody
    • Gamma-secretase subunit Aph-1b antibody
    • Presenilin stabilisation factor like antibody
    • Presenilin-stabilization factor-like antibody
    • PRO 1328 antibody
    • PRO1328 antibody
    • PSFL antibody
    • TAAV 688 antibody
    • TAAV688 antibody
    see all

References

This product has been referenced in:
  • Tanveer R  et al. The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-ß and in the Cortex of Aged Rats. J Biol Chem 287:34709-21 (2012). WB ; Rat . Read more (PubMed: 22891244) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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