The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Predicted molecular weight: 28 kDa.
FunctionProbable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Tissue specificityWeakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
Anterior pharynx defective 1 homolog B (C. elegans) antibody
Anterior pharynx defective 1 homolog B antibody
Anterior pharynx defective 1B like antibody
Anterior pharynx defective 1b short splicing variant antibody
APH 1B antibody
Aph 1beta antibody
Aph1 beta antibody
Gamma secretase subunit APH 1B antibody
Gamma secretase subunit APH1B antibody
Gamma secretase sununit antibody
Gamma-secretase subunit Aph-1b antibody
Presenilin stabilisation factor like antibody
Presenilin-stabilization factor-like antibody
PRO 1328 antibody
TAAV 688 antibody
References for Anti-Aph 1b antibody (ab116657)
This product has been referenced in:
Tanveer R et al. The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-ß and in the Cortex of Aged Rats. J Biol Chem287:34709-21 (2012).
Read more (PubMed: 22891244) »