Overview

  • Product nameAnti-Aph 1b antibody
    See all Aph 1b primary antibodies
  • Description
    Rabbit polyclonal to Aph 1b
  • SpecificityThis antibody reacts with Aph-1b, and also shows some cross reactivity with Aph-1aL/S.
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Aph 1b (C terminal).
    Sequence:

    CQDKNFLLYNQRSRQDKNFLLYNQRSR

  • General notes


    This antibody recognizes a sequence in the Aph-1b C-Terminal Region.

Properties

Applications

Our Abpromise guarantee covers the use of ab24613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 28 kDa.
ICC/IF Use at an assay dependent dilution.

Target

  • FunctionProbable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • Tissue specificityWeakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
  • Sequence similaritiesBelongs to the APH-1 family.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Anterior pharynx defective 1 homolog B (C. elegans) antibody
    • Anterior pharynx defective 1 homolog B antibody
    • Anterior pharynx defective 1B like antibody
    • Anterior pharynx defective 1b short splicing variant antibody
    • APH 1B antibody
    • Aph 1beta antibody
    • APH-1b antibody
    • Aph-1beta antibody
    • Aph1 beta antibody
    • aph1b antibody
    • APH1B_HUMAN antibody
    • Aph1beta antibody
    • DKFZp564D0372 antibody
    • Gamma secretase subunit APH 1B antibody
    • Gamma secretase subunit APH1B antibody
    • Gamma secretase sununit antibody
    • Gamma-secretase subunit Aph-1b antibody
    • Presenilin stabilisation factor like antibody
    • Presenilin-stabilization factor-like antibody
    • PRO 1328 antibody
    • PRO1328 antibody
    • PSFL antibody
    • TAAV 688 antibody
    • TAAV688 antibody
    see all

Anti-Aph 1b antibody images



  • Predicted band size : 28 kDa

References for Anti-Aph 1b antibody (ab24613)

This product has been referenced in:
  • Melo RC  et al. Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes. Nat Protoc 9:2382-94 (2014). Read more (PubMed: 25211515) »
  • Donmez G  et al. SIRT1 Suppresses beta-Amyloid Production by Activating the alpha-Secretase Gene ADAM10. Cell 142:320-332 (2010). WB ; Mouse . Read more (PubMed: 20655472) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"