Overview

  • Product name
  • Description
    Rabbit polyclonal to APH1a
  • Host species
    Rabbit
  • Tested applications
    Suitable for: ChIP, ICC/IF, IP, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide:

    CRRQEDSRVMVYSALRIPPED

    conjugated to KLH, corresponding to C terminal domain of the long isoform of amino acids 245-265 of Human APH1a.

  • Positive control
    • Mouse Brain and Kidney extract (western blot).

Properties

Applications

Our Abpromise guarantee covers the use of ab19390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ChIP Use at an assay dependent concentration.
ICC/IF 1/100.
IP Use at an assay dependent concentration.
WB 1/1000. Detects a band of approximately 18 kDa (predicted molecular weight: 29 kDa).

Target

  • Function
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
  • Tissue specificity
    Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
  • Sequence similarities
    Belongs to the APH-1 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6530402N02Rik antibody
    • AL138795.3 antibody
    • Anterior Pharynx Defective 1 antibody
    • Anterior pharynx defective 1 homolog A antibody
    • APH 1A antibody
    • Aph 1alpha antibody
    • APH-1a antibody
    • Aph-1alpha antibody
    • Aph1a antibody
    • APH1A gamma secretase subunit antibody
    • APH1A_HUMAN antibody
    • CGI 78 antibody
    • CGI78 antibody
    • Gamma secretase subunit APH 1A antibody
    • Gamma Secretase Subunit APH1a antibody
    • Gamma-secretase subunit APH-1A antibody
    • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
    • Presenilin Stabilization Factor antibody
    • Presenilin-stabilization factor antibody
    • PSF antibody
    • UNQ579/PRO1141 antibody
    see all

Images

  • Western blot of APH1a in mouse brain and kidney extracts using ab19390.

  • Immunofluorescence staining of APH1a in Human KNS42 glioma cells using ab19390.

References

ab19390 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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