Overview

  • Product nameAnti-APH1a antibody
    See all APH1a primary antibodies
  • Description
    Goat polyclonal to APH1a
  • Specificityab62821 is expected to recognize both reported isoforms of APH1a (NP_001071096.1 and NP_057106.2).
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    C-HVTDRSDARLQYG

    , corresponding to internal sequence amino acids 58-70 of Human APH1a

  • Positive control
    • Human Brain (Cerebral Cortex) lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab62821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: 1/128000.
    WB: Use at a concentration of 0.05 - 0.1 µg/ml. Detects a band of approximately 29 kDa (predicted molecular weight: 29 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
    • Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
    • Sequence similaritiesBelongs to the APH-1 family.
    • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
    • Information by UniProt
    • Database links
    • Alternative names
      • 6530402N02Rik antibody
      • AL138795.3 antibody
      • Anterior Pharynx Defective 1 antibody
      • Anterior pharynx defective 1 homolog A antibody
      • APH 1A antibody
      • Aph 1alpha antibody
      • APH-1a antibody
      • Aph-1alpha antibody
      • Aph1a antibody
      • APH1A gamma secretase subunit antibody
      • APH1A_HUMAN antibody
      • CGI 78 antibody
      • CGI78 antibody
      • Gamma secretase subunit APH 1A antibody
      • Gamma Secretase Subunit APH1a antibody
      • Gamma-secretase subunit APH-1A antibody
      • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
      • Presenilin Stabilization Factor antibody
      • Presenilin-stabilization factor antibody
      • PSF antibody
      • UNQ579/PRO1141 antibody
      see all

    Anti-APH1a antibody images

    • Anti-APH1a antibody (ab62821) at 0.05 µg/ml + Brain (Cerebral Cortex) lysate (in RIPA buffer) at 35 µg

      Predicted band size : 29 kDa
      Observed band size : 29 kDa

    References for Anti-APH1a antibody (ab62821)

    ab62821 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab62821.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"