Overview

  • Product name
  • Description
    Goat polyclonal to APH1a
  • Specificity
    ab62821 is expected to recognize both reported isoforms of APH1a (NP_001071096.1 and NP_057106.2).
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    C-HVTDRSDARLQYG

    , corresponding to internal sequence amino acids 58-70 of Human APH1a

  • Positive control
    • Human Brain (Cerebral Cortex) lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab62821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: 1/128000.
    WB: Use at a concentration of 0.05 - 0.1 µg/ml. Detects a band of approximately 29 kDa (predicted molecular weight: 29 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
    • Tissue specificity
      Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
    • Sequence similarities
      Belongs to the APH-1 family.
    • Cellular localization
      Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
    • Information by UniProt
    • Database links
    • Alternative names
      • 6530402N02Rik antibody
      • AL138795.3 antibody
      • Anterior Pharynx Defective 1 antibody
      • Anterior pharynx defective 1 homolog A antibody
      • APH 1A antibody
      • Aph 1alpha antibody
      • APH-1a antibody
      • Aph-1alpha antibody
      • Aph1a antibody
      • APH1A gamma secretase subunit antibody
      • APH1A_HUMAN antibody
      • CGI 78 antibody
      • CGI78 antibody
      • Gamma secretase subunit APH 1A antibody
      • Gamma Secretase Subunit APH1a antibody
      • Gamma-secretase subunit APH-1A antibody
      • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
      • Presenilin Stabilization Factor antibody
      • Presenilin-stabilization factor antibody
      • PSF antibody
      • UNQ579/PRO1141 antibody
      see all

    Images

    • Anti-APH1a antibody (ab62821) at 0.05 µg/ml + Brain (Cerebral Cortex) lysate (in RIPA buffer) at 35 µg

      Predicted band size : 29 kDa
      Observed band size : 29 kDa

    References

    ab62821 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab62821.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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