Anti-APH1a antibody - Aminoterminal end (ab62521)

Overview

  • Product name
    Anti-APH1a antibody - Aminoterminal end
    See all APH1a primary antibodies
  • Description
    Rabbit polyclonal to APH1a - Aminoterminal end
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic 13 amino acid peptide from near the amino terminus of human APH1a.

  • Positive control
    • RAW264.7 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab62521 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 29 kDa).

Target

  • Function
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
  • Tissue specificity
    Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
  • Sequence similarities
    Belongs to the APH-1 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6530402N02Rik antibody
    • AL138795.3 antibody
    • Anterior Pharynx Defective 1 antibody
    • Anterior pharynx defective 1 homolog A antibody
    • APH 1A antibody
    • Aph 1alpha antibody
    • APH-1a antibody
    • Aph-1alpha antibody
    • Aph1a antibody
    • APH1A gamma secretase subunit antibody
    • APH1A_HUMAN antibody
    • CGI 78 antibody
    • CGI78 antibody
    • Gamma secretase subunit APH 1A antibody
    • Gamma Secretase Subunit APH1a antibody
    • Gamma-secretase subunit APH-1A antibody
    • Likely ortholog of C. elegans anterior pharynx defective 1A antibody
    • Presenilin Stabilization Factor antibody
    • Presenilin-stabilization factor antibody
    • PSF antibody
    • UNQ579/PRO1141 antibody
    see all

Images

  • Lane 1 : Anti-APH1a antibody - Aminoterminal end (ab62521) at 0.5 µg/ml
    Lane 2 : Anti-APH1a antibody - Aminoterminal end (ab62521) at 1 µg/ml
    Lane 3 : Anti-APH1a antibody - Aminoterminal end (ab62521) at 2 µg/ml

    Lane 1 : RAW264.7 cell lysate
    Lane 2 : RAW264.7 cell lysate
    Lane 3 : RAW264.7 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 29 kDa
    Observed band size : 32 kDa (why is the actual band size different from the predicted?)

References

ab62521 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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