Overview

  • Product nameAnti-APOB48R antibody
    See all APOB48R primary antibodies
  • Description
    Rabbit polyclonal to APOB48R
  • Tested applicationsSuitable for: WB, IHC-P, RIDmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Mouse very low density lipoprotein.

  • Positive control
    • Human Liver tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab125128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 516 kDa.
IHC-P 1/100.
RID Use at an assay dependent concentration.

Target

  • FunctionMacrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
  • Tissue specificityExpressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.
  • Post-translational
    modifications
    There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R).
  • Cellular localizationCell membrane. Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
  • Information by UniProt
  • Database links
  • Alternative names
    • apo b-100 antibody
    • APOB antibody
    • apoB-48R antibody
    • APOBR antibody
    • APOBR_HUMAN antibody
    • Apolipoprotein B receptor antibody
    • Apolipoprotein B-100 receptor antibody
    • Apolipoprotein B-48 receptor antibody
    • Apolipoprotein B48 receptor antibody
    see all

Anti-APOB48R antibody images

  • ab125128 at 1/100 dilution staining APOB48R in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

References for Anti-APOB48R antibody (ab125128)

ab125128 has not yet been referenced specifically in any publications.

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