Overview

  • Product nameAnti-APOBEC3F antibody
  • Description
    Rabbit polyclonal to APOBEC3F
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Synthetic peptide: KPHFRNTVER MYRDTFSYNF YNRPILSRRN TVWLCYEVKT KGPSRPRLDA , corresponding to amino acids 2/51 of Human APOBEC3F

Properties

Applications

Our Abpromise guarantee covers the use of ab87577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceAPOBEC3F is a human protein with natural antiviral activity, especially against HIV. As such, it is currently the subject of intense scientific investigation, and may lead to the development of new therapeutics useful for treating HIV/AIDS. After being packaged into HIV-1 virions, APOBEC3F blocks productive infection by massively editing dC residues to dU on the DNA minus strand during reverse transcription. The editing of the minus strand DNA of HIV-1 during reverse transcription leads to G- to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • Apolipoprotein B mRNA editing enzyme, catalytic polypeptide like 3F antibody
    • ARP8 antibody
    • DNA dC->dU-editing enzyme APOBEC-3F antibody
    • Induced upon T cell activation antibody
    • KA6 antibody
    see all

Anti-APOBEC3F antibody images

  • Anti-APOBEC3F antibody (ab87577) at 1 µg/ml + OVCAR-3 Cell Lysate

References for Anti-APOBEC3F antibody (ab87577)

ab87577 has not yet been referenced specifically in any publications.

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