Overview

  • Product nameAnti-Apolipoprotein D antibody [8CD6]
    See all Apolipoprotein D primary antibodies
  • Description
    Mouse monoclonal [8CD6] to Apolipoprotein D
  • SpecificityAPO-D is localized to steroid-responsive tissues (adrenal cortex, ovary, endometrium, prostate, and pituitary). Apocrine epithelium within axillary skin exhibited strongly positive staining for APO-D, and peripheral nerves, pituitary and renal tubules were also immunoreactive. Expression of Apo-D in the non-malignant prostate gland has not been reported. In paraffin-embedded tissues, Apo-D demonstrates a cytoplasmic staining pattern in some prostate carcinomas.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human).

  • Positive control
    • Prostate carcinoma tissue lysate.
  • General notes


    Apolipoprotein-D (APO-D), a progesterone binding glycoprotein of 24,000 dalton monomer molecular size, is a constituent of high density lipoprotein in plasma, and was first isolated in large quantity as GCDFP- 24, the major protein component of most human breast cyst fluids. In recent studies, Apo-D immunoreactivity has been shown to be an early indicator of prostate cancer and advanced primary prostate tumors.

Properties

Applications

Our Abpromise guarantee covers the use of ab10336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/40. Retrieve antigens with 70% Formic acid for 10-30 minutes at room temperature before commencing with IHC staining protocol.

Target

  • FunctionAPOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
  • Tissue specificityExpressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.
  • Sequence similaritiesBelongs to the calycin superfamily. Lipocalin family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • APO D antibody
    • Apo-D antibody
    • ApoD antibody
    • APOD protein antibody
    • APOD_HUMAN antibody
    • Apolipoprotein D antibody
    • ApolipoproteinD antibody
    see all

Anti-Apolipoprotein D antibody [8CD6] images

  • IHC-P using Ab10336.

References for Anti-Apolipoprotein D antibody [8CD6] (ab10336)

This product has been referenced in:
  • Labrie M  et al. Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake. PLoS One 10:e0130230 (2015). Read more (PubMed: 26083030) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"