Anti-Apolipoprotein L 1 antibody (ab116607)

Overview

  • Product name
    Anti-Apolipoprotein L 1 antibody
    See all Apolipoprotein L 1 primary antibodies
  • Description
    Goat polyclonal to Apolipoprotein L 1
  • Host species
    Goat
  • Specificity
    ab116607 is expected to recognize all three reported isoforms (NP_003652.2; NP_663318.1; NP_001130013.1). Reported variants represent identical protein: NP_003652.2, NP_001130012.1.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    PHASASRPRVTEP

    with a Cysteine residue linker, corresponding to internal sequence amino acids 297-309 of Human Apolipoprotein L 1 (NP_003652.2; NP_663318.1; NP_001130013.1).

  • Positive control
    • Human Placenta lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab116607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 42,45 kDa (predicted molecular weight: 42,46 kDa).

Target

  • Function
    May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
  • Tissue specificity
    Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
  • Involvement in disease
    Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4) [MIM:612551]. It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similarities
    Belongs to the apolipoprotein L family.
  • Post-translational
    modifications
    Phosphorylation sites are present in the extracelllular medium.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • APO L antibody
    • Apo-L antibody
    • ApoL antibody
    • APOL I antibody
    • ApoL-I antibody
    • APOL1 antibody
    • APOL1_HUMAN antibody
    • APOLI antibody
    • Apolipoprotein L antibody
    • Apolipoprotein L I antibody
    • Apolipoprotein L-I antibody
    • Apolipoprotein L1 antibody
    • FSGS4 antibody
    see all

Images

  • Anti-Apolipoprotein L 1 antibody (ab116607) at 0.1 µg/ml + Human Placenta lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 42,46 kDa

References

ab116607 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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