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Apoptosis Inducer Kit (ab102480) contains 5 ready-to-use chemical reagents that induce apoptosis through different mechanisms. Actinomycin D, an antineoplastic antibiotic, inhibits RNA synthesis. Camptothecin, an inhibitor of nuclear topoisomerase, induces apoptosis in many types of cells. Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. Dexamethasone, an active and highly stable glucocorticoid, probably induces apoptosis by binding and activating the intracellular glucocorticoid receptor. Etoposide, a derivative of podophyllotoxin, inhibits topoisomerase activity.
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|Actinomycin D 10mM||Violet||1 x 50µl|
|Camptothecin 2mM||Red||1 x 1ml|
|Cycloheximide 100mM||Green||1 x 1ml|
|Dexamethasone 10mM||Blue||1 x 1ml|
|Etoposide 100mM||Yellow||1 x 100µl|
Our Abpromise guarantee covers the use of ab102480 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Functional Studies||Use at an assay dependent dilution. We recommend using 1000X dilutions for inducing apoptosis in cell cultures. However, the optimal doses may vary for different cells and culture condition.|